Vinegar tastes BAD!

[thomas7g]

This was another dumb idea.

I heard the reason you feel hunger is because without food, your stomach does not produce acid to digest the food. And if your body doesn't detect the acid, it makes you feel hungry.

Also, they said that you can fool your stomach and eliminate your hunger pangs by drinking a tablespoon of vinegar.




GACK! That tasted HOOOORIBLE!!!!!

It burned going down! It went down like Whiskey!!!

okay... I'm not hungry anymore....BUT I'M NOT DOING THAT AGAIN!!!!!!!!

[cranky1c]

Just because you piqued my curiosity.

From the Howard Hughs Medical Institute:

http://www.hhmi.org/news/friedman3.html

March 30, 2001
Mapping the Brain's Food-Intake Circuitry
Researchers have used a genetically altered virus to map the neural inputs that project into regions of the brain that control food intake. According to the scientists, these mapping experiments, which were done in mice, represent an exciting step in understanding the neural circuitry that executes decisions about whether or not to eat.

Howard Hughes Medical Institute investigator Jeffrey M. Friedman and colleagues at The Rockefeller University, Princeton University and the University of California, San Diego (UCSD), used pseudorabies virus to create an elaborate biological tracer that only propagates itself in neurons that express the leptin receptor or neuropeptide Y (NPY), an appetite-stimulating substance found in neurons. The virus, which travels upstream from the site of infection, jumping from neuron to neuron, was engineered to carry a gene for green fluorescent protein. The presence of the fluorescent protein enabled the scientists to trace the path of the virus as it moved through the brain. "The results indicated that a number of factors, including the blood levels of leptin as well as inputs from emotional and higher centers of the brain, contribute to the decision about whether or not to eat," said Friedman.


“It’s not inconceivable to me that individuals who have greater conscious ability to consume less food might have slightly different neural circuitry or more powerful neural connections that might ultimately be visualized through mapping studies.”
Jeffrey M. Friedman

The researchers published their findings in the March 30, 2001, issue of the journal Science. Lead author of the research article is Jeff DeFalco in Friedman’s laboratory, and co-authors include Lynn Enquist and Mark Tomishima at Princeton and Jamey D. Marth, an HHMI investigator at UCSD.

Leptin, which was discovered by Friedman and his colleagues in 1994, is produced by fat tissue and secreted into the bloodstream, where it travels to the brain and other tissues, causing fat loss and decreased appetite. In the brain, leptin affects food intake by acting on distinct classes of neurons in the hypothalamus that express the leptin receptor. However, said Friedman, mapping how the higher centers of the brain affect these neurons is crucial to understanding appetite and food intake.

"It’s obvious that the decision of whether or not to eat has some conscious input," he said. "For example, there is higher cortical input involved in making the decision about whether or not we’re going to skip a meal, try to diet or eat less." If the brain mechanisms behind such decisions were better understood, he said, we might be in a position to better understand the behavioral bases of food intake.

"While our study is only a beginning and doesn’t address such behavioral issues, it’s pretty clear that people differ in how much willpower they have," he said. "And willpower is not a metaphysical thing; it’s a bunch of neural connections and neural circuits. And so, it’s not inconceivable to me that individuals who have greater conscious ability to consume less food might have slightly different neural circuitry or more powerful neural connections that might ultimately be visualized through mapping studies.

"So, now we need to learn how this neural system is organized. And then we can begin to think about what is different about this system in obesity versus leanness; and how the higher circuitry interacts with the circuitry that responds to basic physiological drives."

In mapping the feeding circuitry, Friedman, DeFalco and their colleagues drew on earlier studies by Enquist and other scientists who had used the Bartha strain of pseudorabies virus (PRV) to trace neural circuits. The Bartha strain of PRV can travel "upstream" in neural circuits and it can propagate across neural junctions, called synapses.

However, the scientists wanted to develop a viral tracing system that would specifically label only those hypothalamic neurons expressing the leptin receptor, or those producing neuropeptide Y, an appetite-stimulating peptide found in abundance in certain types of neurons. The scientists found that they could achieve such specificity by building an "off" switch into the virus that was controlled by a protein named Cre. In the engineered virus, Cre is required for PRV to begin replicating. They then targeted Cre to neurons that express either the leptin receptor or NPY. "Once the virus infected these—and only these—cells, the presence of Cre triggers viral replication," said Friedman.

The scientists made certain that they could trace, or follow, the virus by including a green fluorescent protein that would act as a beacon in PRV-infected neurons. "Once the virus is turned on, it’s turned on forever. We traced it backwards to find out which nerve cells send signals to the cells that receive leptin signals," said Friedman. Thus, when the scientists examined slices of mouse brain treated with the virus, they could see which regions of the brain send neurons into the brain's areas known to regulate feeding behavior. "We could see inputs from a number of other regions to the hypothalamus, which is where basic drives for feeding are controlled," he said. "We could see inputs from brain centers that control emotion and from others that receive olfactory inputs. We also saw inputs from centers in the mouse that are the equivalent of centers that control higher cortical or cognitive functions in humans."

"It was not completely unexpected that we would find connections from centers in the brain, such as the amygdala that deals with emotion, that would have an impact on feeding centers in the hypothalamus," said DeFalco. "But the viral tracer also revealed indirect projections—sites that project to sites like the amygdala—which in turn project to the leptin-receptor-expressing neurons in the hypothalamus. That’s where the real power of this technique lies."

While these findings suggest how the system is wired, said Friedman, they are still indirect. "The connections we see suggest that there are inputs and that there will be modulatory effects on feeding from these higher brain regions," he said. "But now we need to understand more about what type of cells these are, what molecules they make and how those molecules might influence the activation state of these neurons that also receive leptin signals."

DeFalco, Friedman and their colleagues are beginning studies using other PRV strains that can follow the connections downward from the higher levels, as well as combinations of viruses engineered with different markers to trace multiple pathways simultaneously. They also plan to explore the hierarchy of the circuitry by using advanced microscopy and computer systems to generate three-dimensional reconstructions of the labeled cells.

[Flamingo Girl]

Vinegar is wine gone bad.

[Darth Marley]

Originally Posted by Flamingo Girl

Vinegar is wine gone bad.

True to an extent.

It seems that ethyl alcohol being processed in the human body is converted to acetic acid, so even good wine becomes vinegar shortly after it is consumed.

Hey, since alcohol turns to acid, maybe your should drink a real drink rather than choking back vinegar.

[thomas7g]

hmmm..... alcohol turns to acid. That makes sense. I wondered why there was no alcohol from vinegar.

No buzz at all folks. It kinda feels like ya tossed your meal. It is not a good feeling.

[bsg1fan1975]

now you see why I only use it in recipies or on sunburns?

[shiningstar]

Thomas .............Just WHAT were YOU thinking?

How did you 'think' vinager would taste. I'm GLAD you aren't doing that again.

[julix]

Tom.........
((((((((((((((((((tom))))))))))))))))))))))))

[shiningstar]

If you must have VINAGER again TOM .......then put it in a salad dressing or in recipies
Thanks for the laughs

[bsg1fan1975]

my elder brother once tried tasting vinegar and nearly ed from the taste. He never did it again!

[shiningstar]

I take it that He learned his lesson quick Bsg

[amberstar]

okay... I'm not hungry anymore....BUT I'M NOT DOING THAT AGAIN!!!!!!!!

(((((((((TOM)))))))))...........YUCK!!!!!!! No wonder you were not hungry any more......LOL

[thomas7g]

Once you have had vinegar straight... you will never try it again.

Once is enough. I never actually tried vinegar by itself before. I've mixed it with vegetable oil. That is what I usually do with it.

Bot that tasted horrible. And it felt worse!

But I am fine now.

[Gemini1999]

Originally Posted by thomas7g

Once you have had vinegar straight... you will never try it again.

Once is enough. I never actually tried vinegar by itself before. I've mixed it with vegetable oil. That is what I usually do with it.

Bot that tasted horrible. And it felt worse!

But I am fine now.

Tom -

I gotta ask - why these extreme measures to curb your appetite?

Just curious...

Bryan

[BST]

On a side note about vinegar, if you like green vegetables-- peas, green beans, broccoli, spinach, etc... then, either steam or boil the veggie and add a capful or teaspoon of vinegar (per serving).

For me,

[thomas7g]

Originally Posted by Gemini1999

Tom -

I gotta ask - why these extreme measures to curb your appetite?

Just curious...

Bryan

stupidity mostly. I heard that on an infomercial and decided to try it out.


I just wanted to stop that hunger urge I get at night just before going to bed.

[Gemini1999]

Originally Posted by thomas7g

I just wanted to stop that hunger urge I get at night just before going to bed.

Tom -

That hunger "urge" or otherwise known as a "hunger pang" is very commonly misunderstood. The feeling in your stomach isn't really telling you that you are hungry, it is actually a learned physical process. When you eat at certain times of the day for a long time, your body becomes accustomed to that routine. When you eat and the food arrives in your stomach, your body produces the necessary acids, etc. to help digest the food. Your stomach also contracts to compact the digested food so it is small enough to move on through the body.

The thing is, if we skip a meal, your brain might be aware of it, but the body keeps on with the stomach processes even though it hasn't been fed at the normal interval. Your stomach still contracts and produces the acids even though there is nothing to break down. That is why we have that feeling in our stomach when we don't eat.

Are you normally prone to snacking in the evening or eat late sometimes? I know a few people that like to have a snack before bedtime - for me, it just keeps me awake longer, so I avoid it. I think that even though you are busy, if you take the time to eat something even if only a quick sandwich, it's better than skipping a meal.

If you really must have a snack before bed - I would avoid anything that has a lot of sugar, caffeine or carbs in it. These things usually ramp up your blood sugar and wind up enervating you instead of letting you sleep.

I hope this helps a bit...

Bryan

[thomas7g]

It started at art school. My bud got me addicted to midnight cookies...now I want to get off that. BUt I get very hungry around midnight. Can['t stop....

[bsg1fan1975]

Originally Posted by shiningstar

I take it that He learned his lesson quick Bsg

yup he did!

[Flamingo Girl]

Try a glass of milk.

[ernie90125]

have chips with vinegar. That way you won't feel hungry because you have had the chips, and you'll still have had the vinegar.... Great idea eh !?!

Or am I missing the point

:-))))))))))

[Ian_W359]

A friend of my brother once mistook a bottle of vinegar for a bottle of wine! (because my dad had stored a lot of vinegar in wine bottles! oops!) Can't stand the stuff myself though...



Ian W359

[thomas7g]

FG- I'll try that

[shiningstar]

Well Thomas you can always threaten yourself with the vinager again

[Senmut]

Originally Posted by thomas7g

This was another dumb idea.

I heard the reason you feel hunger is because without food, your stomach does not produce acid to digest the food. And if your body doesn't detect the acid, it makes you feel hungry.

Also, they said that you can fool your stomach and eliminate your hunger pangs by drinking a tablespoon of vinegar.




GACK! That tasted HOOOORIBLE!!!!!

It burned going down! It went down like Whiskey!!!

okay... I'm not hungry anymore....BUT I'M NOT DOING THAT AGAIN!!!!!!!!

Okay, and your IQ is WHAT.....?????

[thomas7g]

Originally Posted by Senmut

Okay, and your IQ is WHAT.....?????

I swear, its a positive number!!!!!

[shiningstar]

Originally Posted by Senmut

Okay, and your IQ is WHAT.....?????

He's like my husband ........He'll try ANYTHING once